Bokurano
The 24 episode adaptation and 8 volume manga make the series Bokurano. The director of the anime didn’t like the ending to the manga, so he was given permission to change it as long as it wasn’t magical. This mecha is more a drama about humanity more than anything. Each kid dies after they pilot the mystery mech that they use to fight the invading mechs. With each death, one of the lights on the mech goes out. The ending parts that reveal why they’re fighting is truely sad. Don’t Wiki it.

Oh! Edo Rocket
Character have blue outlines, the story is about sending a girl to the moon, there are many exaggerated characters, and it’s all based on a play. Nobody watched it.

Ookiku FuriKabutte
Baseball anime is an instant hit. Two boys do very well in baseball in middle school. However they move on to high school where they have a new manager of the team. Someone they’re not already close to. Friends, gaining confidence, and becoming worthy.

Doujin Work
An anime based on a manga about getting a girl into the doujin world. Conventions, learning to draw such manga, and…she tends to be the loud character.
Other good mentions would be Tales of Symphonia, Potemayo, and perhaps Ghost Hound.